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It’s best to talk to your doctor before starting supplementation, especially if you’re taking other medications or have any underlying health conditions. According to Schleiger, vitamin D supplements may interact with certain medications, including corticosteroids and medications for seizures or high cholesterol. She also adds that high-dose supplements might not be suitable for people with specific health conditions, such as hyperparathyroidism, sarcoidosis or kidney disease. If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. It is recommended that you take vitamin D if you have a deficiency, or to prevent a deficiency if you:
Though vitamin D3 is available in supplements and several food sources, you can also meet your needs by getting regular sun exposure. This is because the skin produces vitamin D when exposed to ultraviolet rays from the sun. A review published in 2015 noted that adverse effects have been reported only at 25(OH)D serum concentrations above 200 nmol/L. [153] The percentage of the population taking over 1000 IU/day, as well as the percentage taking over 4000 IU/day, have both increased since 1999, according to trend analysis. [165] a b c "Cholecalciferol (Professional Patient Advice) - Drugs.com". www.drugs.com. Archived from the original on 30 December 2016 . Retrieved 29 December 2016.Osteomalacia is a disease in adults that results from vitamin D deficiency. [1] Characteristics of this disease are softening of the bones, leading to bending of the spine, proximal muscle weakness, bone fragility, and increased risk for fractures. [1] Osteomalacia reduces calcium absorption and increases calcium loss from bone, which increases the risk for bone fractures. Osteomalacia is usually present when 25-hydroxyvitamin D levels are less than about 10 ng/mL. [51] Although the effects of osteomalacia are thought to contribute to chronic musculoskeletal pain, there is no persuasive evidence of lower vitamin D levels in people with chronic pain [52] or that supplementation alleviates chronic nonspecific musculoskeletal pain. [53] Osteomalacia progress to osteoporosis, a condition of reduced bone mineral density with increased bone fragility and risk of bone fractures. Osteoporosis can be a long-term effect of calcium and/or vitamin D insufficiency, the latter contributing by reducing calcium absorption. [2] Use of supplements [ edit ]
A deficiency of vitamin D can have serious consequences in the body. Vitamin D is vital for these reasons: Chemically, the various forms of vitamin D are secosteroids, that is, steroids in which one of the bonds in the steroid rings is broken. [16] The structural difference between vitamin D 2 and vitamin D 3 is in the side chain, which contains a double bond, between carbons 22 and 23, and a methyl group on carbon 24 in vitamin D 2. [4] Many vitamin D analogues have been synthesized. [4] Biology [ edit ] Calcium regulation in the human body. [17] The role of active vitamin D (1,25-dihydroxyvitamin D, calcitriol) is shown in orange. A 2013 Study in the Journal of Lipids found vitamin D deficiency was associated with dyslipidemia (2). Dyslipidemia is elevated blood levels of either Triglycerides, Cholesterol or both. Sintzel MB, et al. Vitamin D and Multiple Sclerosis: A Comprehensive Review. Neurol Ther. 2018;7(1):59-85.
More about Vitamin D3 (cholecalciferol)
Over 18% of the population exceeds the NIH daily recommended allowance ( RDA) of 600–800 IU, [2] by taking over 1000 IU, which suggests intentional supplement intake. [165] Vitamin D3, also known by its other alias cholecalciferol, is vitamin D in its natural form–the kind produced in your body as it absorbs sunlight. However, recent studies are beginning to find that vitamin D2 may be as effective as vitamin D3. Vitamin D toxicity is treated by discontinuing vitamin D supplementation and restricting calcium intake. Kidney damage may be irreversible. Exposure to sunlight for extended periods of time does not normally cause vitamin D toxicity. The concentrations of vitamin D precursors produced in the skin reach an equilibrium, and any further vitamin D produced is degraded. [158] Biosynthesis [ edit ] A 2012 study done over 12-weeks showed supplementation with Vitamin D3 did result in a decrease in overall fat mass (1). A couple of things to note:
Brouwer DA, van Beek J, Ferwerda H, Brugman AM, van der Klis FR, van der Heiden HJ, Muskiet FA (June 1998). "Rat adipose tissue rapidly accumulates and slowly releases an orally-administered high vitamin D dose". The British Journal of Nutrition. 79 (6): 527–532. doi: 10.1079/BJN19980091. PMID 9771340. We investigated the effect of oral high-dose cholecalciferol on plasma and adipose tissue cholecalciferol and its subsequent release, and on plasma 25-hydroxyvitamin D (25(OH)D). ... We conclude that orally-administered cholecalciferol rapidly accumulates in adipose tissue and that it is very slowly released while there is energy balance. Vitamin D overdose causes hypercalcemia, which is a strong indication of vitamin D toxicity – this can be noted with an increase in urination and thirst. If hypercalcemia is not treated, it results in excess deposits of calcium in soft tissues and organs such as the kidneys, liver, and heart, resulting in pain and organ damage. [24] [29] [167] Everyone can benefit from taking colecalciferol as a daily vitamin D supplement. Adults who are not at risk of vitamin D deficiency should consider taking a daily supplement of 10 micrograms of vitamin D during autumn and winter. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl: 10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.If you are taking the chewable tablet or wafers, chew the medication thoroughly before swallowing. Do not swallow whole wafers. The upper tolerable limit for supplementation is 4,000 International Units per day, according to Dr. White. And while he does note that this amount is most likely conservative, 4,000IU is still more than most people need to take. Because Vitamin D and calcium are related too much Vitamin D can lead to Calcium issues. These issues include, Hypercalcemia, Kidney Stones and Kidney damage. Tripkovic L, Lambert H, Hart K, Smith CP, Bucca G, Penson S, etal. (June 2012). "Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis". The American Journal of Clinical Nutrition. 95 (6): 1357–64. doi: 10.3945/ajcn.111.031070. PMC 3349454. PMID 22552031.
Cholecalciferol, also known as vitamin D 3 and colecalciferol, is a type of vitamin D that is made by the skin when exposed to sunlight; it is found in some foods and can be taken as a dietary supplement. [1] Haridy R (28 February 2022). "One type of vitamin D found to boost immune system, another may hinder it". New Atlas . Retrieved 7 April 2022. Shieh A, et al. Effects of High-Dose Vitamin D2 Versus D3 on Total and Free 25-Hydroxyvitamin D and Markers of Calcium Balance. J Clin Endocrinol Metab. 2016 ;101(8):3070-8. A meta-analysis of observational studies showed that children with ADHD have lower vitamin D levels, and that there was a small association between low vitamin D levels at the time of birth and later development of ADHD. [96] Several small, randomized controlled trials of vitamin D supplementation indicated improved ADHD symptoms such as impulsivity and hyperactivity. [97] Depression [ edit ] A study published in 2017 assessed the prevalence of high daily intake levels of supplemental vitamin D among adults ages 20+ in the United States, based on publicly available NHANES data from 1999 through 2014. Its data shows the following:Adequate calcium and regular exercise may help to achieve strong bones in children and adolescents and may reduce the risk of osteoporosis in older adults. An adequate intake of vitamin D is also necessary." [112] Your skin is your largest organ and vitamin D is critical to its health. The active form of Vitamin D (calcitriol) helps with skin repair and growth. Vitamin D3 is the precursor to Calcitriol. As you get older your body loses the ability to produce D3 which leads to a weaker immune system and weaker skin. 3) Healthy Muscles If you are taking the rapidly-dissolving tablets, dry your hands before handling the medication. Place each dose on the tongue, allow it to dissolve completely, and then swallow it with saliva or water. You do not need to take this medication with water.
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